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doi: 10.1021/acsmedchemlett.1c00150

TCF/LEFs and Wnt signaling in the nucleus

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CRC is the third most commonly diagnosed cancer in the world (38) and has a higher prevalence in acromegalic patients with respect to the general population (3941), reducing the responsiveness of cells to Transforming Growth Factor Beta (TGF) (42), enhancing the anti-apoptotic effects of both Cyclooxygenase-2 (Cox-2) (43) and Bcl2 Like 1 (Bcl-X L) (44), and enhancing the expression of the pro-angiogenetic Vascular Endothelial Growth Factor (VEGF) (45, 46)