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40, 41 To avoid cellular and DNA damages, ROS concentration is tightly regulated during liver regeneration, and this process is achieved at least in part by the cytoprotective transcription factor Nrf2

This makes it hard for tissues to get the oxygen they need

Notch signaling in the vasculature: angiogenesis and angiocrine functions

Such approaches are expected to make gene therapies more available due to lower overall costs and elimination of advanced cell processing units currently needed to generate the ex vivo modification and expansion of gene-modified cell therapies