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Identification of cytoskeletal [14C]carboplatin-binding proteins reveals reduced expression and disorganization of actin and filamin in cisplatin-resistant cell lines

One possible cause is the insufficient drug levels in the brain

By restoring proper levels of B12 these symptoms usually improve
In studies conducted in nude mice, a significant delay in tumor growth was observed with the administration of R-goniothalamin alone or in combination with cisplatin

[DOI] [PMC free article] [PubMed] [Google Scholar] 158.Lucena M.I., Andrade R.J., de la Cruz J.P., Rodriguez-Mendizabal M., Blanco E., Snchez de la Cuesta F