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With respect to autoregulatory function, there is new interest in miRNA-mediated regulation of vascular responsiveness

K.SpechtC

Nat Chem Biol 13:10811087

In a recent study by Pfizer to examine patients initiating Xeljanz (tofitinib, Janus kinase inhibitor) for the treatment of moderate to severe active rheumatoid arthritis in combination with oral methotrexate (MTX), patient enrollment comprised those who have received Au treatment in the form of auranofin, aurothioglucose, or sodium gold thiomalate during a 15.2 years period before the index date

Given that the MEOS pathway for ethanol metabolism is induced in chronic alcoholics, the enhanced ethanol metabolism likely contributes to alcoholics metabolic tolerance for ethanol which in turn promotes further alcohol consumption