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You know, it's not something that I'm intimately familiar with, but I'm open to understanding and trying to research and get a better grasp
However, it should be noted that Nrf2 does not regulate the expression of any autophagy-related genes, suggesting that Nrf2 may not directly activate autophagy but indirectly facilitates autophagy activation and degradation in cardiomyocytes (Wang et al., 2014)

While inflammatory signalling mechanisms are well understood, we know very little about what metabolic changes occur because of, or even preceding, these inflammatory reactions

Sodium-glucose cotransporter 2 inhibitors induce anti-inflammatory and anti-ferroptotic shift in epicardial adipose tissue of subjects with severe heart failure

[DOI] [PubMed] [Google Scholar] 7.Sucic M, et al
