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We identified several mutated nrf2a alleles harboring insertion, deletion, or a mix of both and selected an allele presenting a deletion of 5 nucleotides between the nucleotides 1450 and 1454 of the reference coding sequence, this deletion is in the exon 5 before the DNA binding domain of the nrf2a protein (hereafter referenced as nrf2a5 ) (Fig 1A)

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J Biol Chem 272(52):3301533022

A subsequent study of Irie and colleagues in 2016 showed that the use of oral glutathione, at a daily dosage of 300 milligrams per day, may prevent NASH progression from NAFLD (78)