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In the subsequent non-comparative study from the same research group, 1097 patients were included

Microbiome and Asthma: Microbial Dysbiosis and the Origins, Phenotypes, Persistence, and Severity of Asthma

Conclusions There is evidence supporting the use of Lcarnitine in treating hyperammonaemia and hepatotoxicity following chronic therapeutic use and after acute overdose of valproic acid, but the optimal dose and route of administration is unknown

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Similar to the RoA, additional investigation based on subgroup analysis of dosage and duration of treatment revealed no significant SMD in subgroups (Supplementary Figure 2)