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Abstract Metabolic flexibility describes the ability of cells to respond or adapt its metabolism to support and enable rapid proliferation, continuous growth, and survival in hostile conditions

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CB-839 was investigated in a phase II clinical trial comparing the addition of CB-839 to cabozantinib in metastatic renal cell carcinoma, however, there was no improvement to progression free survival in the patients who received CB-839 (Tannir et al., 2022)

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It is possible that HDL-C levels may simply be a biomarker for CVD and not play a causal role in atherosclerosis
