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Here, the novel finding in our study is that D1/D5 and SK1-3 activation increased ROS production and the effect was probably mediated by the cell membrane hyperpolarization because a depolarization (caused by KCl) decreased but a hyperpolarization (caused by NS309 plus TRAM-34) increased ROS production

doi: 10.3389/fphar.2020.590855 Received 03 August 2020 Accepted 18 September 2020 Published 15 October 2020 Volume 11 - 2020 Edited by Efstratios Stratikos, National Centre of Scientific Research Demokritos, Greece Reviewed by Marcin Poreba, Wrocaw University of Science and Technology, Poland Akira Hattori, Kyoto University, Japan Updates Copyright 2020 Hallberg and Larhed