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Importantly, markers of neurogenesis have been reported in adult human brain specimens following stroke (Moreno-Jimnez et al., 2019)

(2020) Brain parenchymal and extraparenchymal macrophages in development, homeostasis, and disease

This relationship creates a destructive cycle: stress lowers BDNF, which impairs the hippocampal circuits that regulate stress responses, which leads to more cortisol production and further BDNF reduction
