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(60) However, studies are still inconclusive because increased activity of the ADH (ADH1*B2) enzyme and decreased activity of the ALDH (ALDH2*2) enzyme have also been described

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Later refinements by Wolfe and Liu (2008), such as the use of HepG2 liver cells and the peroxyl radical generator ABAP, enhanced its physiological relevance by integrating parameters like antioxidant uptake and metabolism