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Here, we treated a D2.B10-Dmdmdx/J (D2-mdx) model of DMD (910 wk old) with mitochondrial division inhibitor 1 (Mdivi-1), a selective Drp1 inhibitor, every other day (intraperitoneal injection) for 5 wk

With aging, the gradual accumulation of atherosclerotic risk factors, including oxidative stress, inflammation, dyslipidemia, and hyperglycemia, drives metabolic reprogramming in ECs, particularly in regions exposed to disturbed flow with OS, ultimately leading to EC dysfunction and atherosclerosis