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Through a series of structure-activity relationship (SAR) studies, the authors optimized the peptide sequence and introduced a C20 fatty diacid via a -glutamic acid linker to the N-terminus

doi: 10.1016/j.ijpharm.2023.122759 [DOI] [PubMed] [Google Scholar] 43.Pandit R, Chen L, Gtz J

The rats were kept in cages and maintained under standard husbandry conditions (12:12 h light/dark cycle, controlled room temperature (23 2C), stress-free, ad libitum water, standard diets, and sanitary conditions)

Selective immortalization of murine macrophages from fresh bone marrow by a raf/myc recombinant murine retrovirus

Data pooling challenges : Trials that switch from comprehensive to selective data capture midstream may face analytical complexity (ICH, 2022, Section 4)