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7981 Though cannabinoids like THC and PEA have been shown to reduce itching in murine models, 82 the human clinical data for testing the antipruritic potential of PEA have resulted in conflicting results

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For example, a subset of patients exhibited increased expression of the Caps2 isoform Caps2-dex3 , which lacks a region that binds to dynactin 1, resulting in altered localization of CAPS2 and altered BDNF transport [11]

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doi: 10.1159/000177696