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Some insurers require documented trial of oral supplementation before approving injections, though this contradicts the pathophysiology-patients with true intrinsic factor deficiency cannot absorb oral B12 regardless of dose

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Vitamin B12 serves as a cofactor for methionine synthase, an enzyme involved in methylation reactions

Major medical sources note very limited research on lipotropic injections for weight loss, and that any weight change is often more attributable to the overall program (nutrition, activity, calorie intake) than the injection alone

Nygard O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M, Vollset SE