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While several enzymatic (such as superoxide dismutase, catalase, glutathione peroxidase) and non enzymatic (such as 4-hydroxynonenal, decrease of glutathione, vitamin E, vitamin C, malondialdehyde) markers of chronic oxidative stress in liver are well known, early protein targets of oxidative injury are yet not well defined

A deficiency in vitamin B12 can lead to symptoms such as fatigue, brain fog, irritability, tingling sensations in the extremities, and even depression

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