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Compared to VEGF neutralizing antibodies, TKI do not interfere with the binding of VEGF to its receptors and they usually target not only VEGFR but additionally other kinases, such as PDGFR, FGFR and c-KIT (9)

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With promising advancements on the horizon, including novel agents such as mirogabalin and vixotrigine and innovative approaches like high-frequency spinal cord stimulation, the treatment landscape continues to evolve toward better long-term outcomes

Changes in intestinal microbial flora can alter the barrier function and permeability of the gut and subsequently influence the immune system (140, 149), and have been linked to PD (149)