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The Wnt signaling pathway, along with its interplay with other signaling pathways, emerges as a critical regulator of the occurrence and progression of I/R injury

A model incorporating both genetic and epigenetic mechanisms in the manifestation of OCD is suggested as a heuristic for the pathophysiology of OCD

Through a variety of physiological pathways involving many receptors, such as P2X7, toll-like receptor 4 (TLR4), and other unidentified receptors, hemolyzed red blood cells release heme and ATP, which act as damage-associated molecular patterns (DAMPs) and activate endothelial cells, neutrophils, and macrophages

(Singapore: Springer), 189208

This is particularly relevant for small, frequent doses from large vials