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Bursal and Glin 2011)

Its hallmarks include elevated intracellular lipid ROS levels, reduced mitochondrial volume with increased membrane density, diminished or vanished cristae, and ruptured outer mitochondrial membranes [8]

By 2028, PCSK9 inhibitors could become multifunctional medicines that address both lipid metabolism and inflammation, with gene-editing technologies potentially offering remedies for familial hypercholesterolemia

Using these criteria, the female-to-male ratio is closer to 2:1 than previous estimates of up to 6:1
doi: 10.1016/j.optmat.2025.117144 3 AmorN
