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Subsequently, in 2004, a multicenter controlled clinical trial (N = 682 LOE1b) showed that LC treatment was superior to placebo in relieving pain, improving nerve fiber regeneration and vibration perception in patients with diabetic PNSD [73]
Katalinic D, Anic B, Stern-Padovan R, Mayer M, Sentic M, Cikes N et al
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Moreover, dietary supplementation with TMAO significantly decreased the expression of both enteral cholesterol transporters Niemann-Pick C1-like1 (Npc1L1), which transports cholesterol into enterocytes from the intestinal lumen, and ABCG5/8, which transports cholesterol out of enterocytes into the gut lumen (Jia et al., 2011
