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Overall, the effect of GLP-1RAs on muscle mass shows a high degree of heterogeneity in clinical trials: some studies report that lean body mass reduction accounts for 40% to 60% of total weight loss, while others indicate that the proportion of lean body mass reduction is approximately 15% or lower [50]

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PLoS One (2012) 7(8):e44136.10.1371/journal.pone.0044136 241 CuneoRCHickmanPEWallaceJDTehBTWardGVeldhuisJDet alAltered endogenous growth hormone secretory kinetics and diurnal GH-binding protein profiles in adults with chronic liver disease

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