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So if any preservative was added to the solution, it may very well be the cause of any side effect

Bacterial growth can occur despite refrigeration

van Bloemendaal L, Veltman DJ, ten Kulve JS, et al

Driving more of any active into the dermis can increase both effect and irritation

However, at present, the effect of the application of exogenous VEGF in tendon healing is controversial, as the role of endogenous VEGF in tendons has also not been fully elucidated
