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This reduces tumor initiation ability while simultaneously increasing the expression of solute carrier family 7 member 11 (SLC7A11), which protects tumor cells from lipid peroxidation and ferroptosis that promote tumor metastasis

Overall, the underlying pathophysiological mechanism of bone fragility in diabetes is very complex, including hyperglycemia, oxidative stress, and the accumulation of advanced glycosylation end products, which will damage the characteristics of collagen, increase bone marrow obesity, release inflammatory factors and adipokines from visceral fat, and may change the function of bone cells

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However, this hypothesis has not been exhaustively tested and may also vary between drugs of abuse

Compared with vehicle injection, retinal BF measured with MBR was reduced by 13% for 20 min after ET-1 injection (Fig 1A and B)