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For retatrutide , phase 2 data published in the New England Journal of Medicine (2023) demonstrated substantial mean weight reductions over 48 weeks in adults with obesity among the highest figures reported for any pharmacological agent to date

[DOI] [PMC free article] [PubMed] [Google Scholar] 164

For patients losing significant weight on compounded semaglutide or tirzepatide, topical GHK-Cu is sometimes used to support skin elasticity, though specific evidence in this population is limited