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The sorted cells were washed twice with 50 mL phosphate-buffered saline to remove the FreSHtracer and then further cultivated in culture medium for 24 h prior to in vitro or in vivo experiments, as described below

10.1007/s43032-025-01832-8 72 KhodamoradiK.GolanR.DulleaA.RamasamyR

Activation of Nrf-2 occurs primarily through two mechanisms: increased transcription of the Nrf-2 gene and enhanced release of Nrf-2 from its cytoplasmic inhibitor Kelch-like ECH-associated protein 1 (Keap1) (Ngo and Duennwald, 2022)

When we mutated the cleavage site from UUGCAA to UUCCAA, fragment #4 as well as the full-length fragment was no longer cleaved by IRE1 (Fig

N., Osteoporosis, Clinical Orthopaedics and Related Research no