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This study uses smart nanomaterials to treat OA with a synergistic strategy that both remodels senescent cartilage and creates a pro-chondrogenic microenvironment.

Method Forty-two healthy older adults aged 5570 years were randomized to receive either a novel L-Carnitine (1500 mg), L-leucine (2000 mg), creatine (3000 mg), Vitamin D3 (10 g) (L-Carnitine-combination) product (n=14), L-Carnitine (1500 mg) (n=14), or a placebo (n=14) for eight weeks

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