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The conventional adenoma-carcinoma pathway occurs after a genomic event triggered by adenomatous polyposis coli mutation, followed by P53 loss of function or KRAS activation, whereas the serrated tumour pathway is characterised by a CpG island methylation phenotype

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The liver involvement results in hepatomegaly and the muscle involvement results in weakness

Therefore, IGF2R may act as a tumor suppressor by preventing IGF1R activation

To avoid unwanted reactions, the recommended dosage on the packaging of the respective product should be observed