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In a controlled study, variation in ischemia/reperfusion tolerance across time of day has been previously explored, showing an increase in infarct volume and fibrosis at the onset of activity (ZT12) compared to the beginning of the inactive period (ZT0) in WT mice (Weil et al., 2009)
T2D had been associated with increased intestinal permeability, able to cause penetration of bacteria across gut barrier, resulting in metabolic endotoxaemia and determining low-grade systemic inflammation [53]
& Hutt, M
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Nature 2011;472:57-63
