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If an individual has autoimmune atrophic gastritis, the body will not produce enough intrinsic factors or stomach acid
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de Levia, Brugus, de Leiva-Prez
Research dating back to the early 2000s has demonstrated that estradiol can activate mast cells through a non-genomic estrogen receptor alpha pathway and trigger calcium influx, leading to degranulation and release of histamine, tryptase, prostaglandins, leukotrienes, and inflammatory cytokines

Spoel and Dong 2024)
