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Views of aging and senescence frequently highlight a deterioration in mitochondrial health and function with age, and investigations of NAD+ depletion and the associated oxidative stress and damage corroborate these theories (1-2)
The choice depends on the patients health, how bad the deficiency is, and the doctors advice
NICE guidance recommends 1 mg hydroxocobalamin three times weekly for 2 weeks for patients without neurological symptoms, with lifelong maintenance therapy for irreversible causes
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