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After pre-processing the model systems were solvated in a cubical water box (TIP3P water model) keeping 10 buffer space in x, y, and z dimensions

Heptanoate can be metabolized to propionyl-CoA, producing succinyl-CoA after carboxylation and thereby re-filling a key substrate of the tricarboxylic acid (TCA) cycle [167]

Triathlon Magazine: Because of vitamin B12s influence on red blood cells and oxygen transport in the body, it plays a vital role in a triathletes energy levels, health, training and performance

Motavalli et al., 2021

Similarly, theres Yellowstone Lake in Wyoming, USA, sitting at 2,356 m/7,730 ft elevation with a maximum depth of 125 m/409 ft