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Committee for Medicinal Products for Human Use (19 February 2021)

While the rotator cuffs are often naturally harmed as we age, repairing them has shown to be difficult

It is commonly investigated in preclinical research models relating to peptide signalling pathways, cellular communication mechanisms, and copper-associated biological processes

Moreover, PHA665752 supressed cell proliferation, and induced apoptosis in MHCC97-L and MHCC97-H cells which overexpress c-Met through blocking phosphorylation of c-Met and downstream PI3K/Akt and MAPK/Erk pathways (You et al., 2011)

doi: 10.1371/journal.pgen.1006950 273 KirschkeCPHuangL