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Rediger and colleagues showed that the signalling modalities of one GPCR was dependent on the conformational activity of the other

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[ref] CYP2E1 and oxidative pathway: The liver breaks down most of the acetaminophen using sulfation and glucuronidation reactions, allowing for easy excretion

Vaughan TJ, Osbourn JK & Tempest PR (1998) Human antibodies by design
