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Patients should be reviewed 812 weeks after commencing treatment to assess: Symptomatic improvement, particularly resolution of fatigue and neurological symptoms Haematological response (normalisation of haemoglobin and mean cell volume) Reticulocyte count typically rises within one week, indicating bone marrow response Repeat serum B12 testing is generally not useful after starting parenteral therapy, as levels remain elevated for months

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It can also help improve cognitive functioning, and increases libido in patients who are on Testosterone Replacement Therapy (TRT)

Some studies suggest that an increased intake of B12 may help to resynchronize sleep cycles and normalize sleep patterns, but other studies have come to no such conclusions