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It can only be made by excluding other known conditions or risk factors that lead to renal insufficiency and assessing exposure to nephrotoxins, which has to be consistent with known dose-effect/response relationships and with the temporal sequence of events leading to the observed effect

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2009), they are also implicated in a variety of other physiological processes, including stress response, respiration, food intake, gastrointestinal motility, as well as endocrine and immune responses (Le Merrer et al

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