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Directly, ATF3 facilitates ferroptosis by regulating genes that play vital roles in iron management and the initiation of lipid peroxidation (115,117)

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For instance, pharmacokinetic vitamin-drug interaction studies have indicated a decreased uptake of the anticancer drug antifolate methotrexate in cancer cells, and the complexation of methotrexate and doxorubicin C into inactive adducts by riboflavin, thereby reducing the efficacy of these drugs 145

[DOI] [PubMed] [Google Scholar] [22].Clement GE, Hartz TP, Determination of the microscopic ionization constants of cysteine, J