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And they didnt have a safety signal

Int Immunopharmacol 138:112561 Elgewelly MA, Elmasry SM, Sayed NSE, Abbas H (2022) Resveratrol-loaded vesicular elastic nanocarriers gel in imiquimod-induced psoriasis treatment: in vitro and in vivo evaluation
They act according to the pH and temperature of the environment and deliver its content
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Disseminated Penicillium marneffei infection diagnosed on examination of a peripheral blood smear of a patient with human immunodeficiency virus infection