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Cell and tissue research , 377 (2), 153159

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Thus, primary evidence is supplemented by authoritative sources including NIH.gov (PubChem, ClinicalTrials.gov) and Cleveland Clinic educational materials due to limited recent peer-reviewed publications on this specific query

In contrast, it would appear that the neurologic effects of cobalamin deficiency are due to metabolic disturbances unrelated to purine synthesis because the neurologic deficits may develop independently of the hematologic abnormalities, and folate supplementation will not prevent or reverse these deficits

Then, put the cold pack back on for another 1-2 minutes