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Curcumin, a natural polyphenolic metabolites, has been shown in a systematic review of the literature to significantly reduce oxidative stress and exhibit antioxidant effects through multiple biological pathways, including inhibition of reactive oxygen species generation, upregulation of antioxidant enzyme expression, and regulation of lipid metabolism-related gene expression

Exploring the active site of plant glutaredoxin by site-directed mutagenesis

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Eur J Vasc Endovasc Surg

PKM2 also controls flux into the serine biosynthesis pathway [42], which supports glutathione production [43, 44]