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Pande and Flora [69] reported that a combination of lipoic acid and thiol chelator was able to alleviate lead toxicity, and in particular, it reduced oxidative stress and lead levels in the brain

Among the diet-associated metabolites with increased abundance, 4-hydroxyphenylacetate (4-HP) displayed significance specific only to the de novo PD vs

Formulation alternatives may provide relief: Different tablet formulations with alternative inactive ingredients may be better tolerated Liquid preparations can be easier to tolerate and allow flexible dosing Intramuscular injections completely avoid the gastrointestinal tract and are particularly useful for those with absorption issues (such as pernicious anaemia or malabsorption) or persistent oral intolerance Review inactive ingredients: Examine the supplement label for potential irritants or allergens

CRC Press, Boca Raton, pp 7182 [Google Scholar] Chen JH, Ho CT (1997) Antioxidant activities of caffeic acid and its related hydroxycinnamic acid compounds