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Oxidative Med Cell Longev 2017:132 Jessie SW, Krishnakantha T (2005) Inhibition of human platelet aggregation and membrane lipid peroxidation by food spice, saffron

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Activated SIRT1 deacetylates PGC-1 resulting in increased transcriptional activity and thus, enhanced mitochondrial biogenesis Therapeutic Intervention for Hyperglycemia Many, if not all, of the vascular consequences of insulin resistance are due to the persistent hyperglycemia seen in type 2 diabetes

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Its ability to calm chronic inflammation is of interest more broadly, since inflammation plays a role in common health concerns like heart disease, diabetes, and cancer