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The failures in many antioxidant clinical trials likely arise from starting the therapies in the late stages of AD, not monitoring drug levels and markers for the in vivo therapeutic effect of the drug, not utilizing a multi-antioxidant approach that covers both lipophilic and hydrophilic areas of the cell or recycle the oxidized antioxidants back to the reduced state, and not taking into account the basal redox status of the subjects in the trials [10

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Formulation & evaluation of PLGA nanoparticles of ropinirole HCl for targeting brain

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Finally, we call for the development of quantitative prediction algorithms, leveraging machine learning to model how food processing and cooking parameters affect the generation of these hormetins