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Activation of this pathway results in protein synthesis, hypertrophy and inhibition of the key ubiquitin ligase atrogin-1 by inactivating Foxo factors[82], IGF-IR also phosphorylates Shc, which subsequently activates the RAS/Raf/MEK pathway leading to cell proliferation and mitogenesis[2]

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10.1016/j.biopha.2019.109729 134 WangQ.OuY.HuG.WenC.YueS.ChenC.et al (2020b)

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