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Activation of this pathway results in protein synthesis, hypertrophy and inhibition of the key ubiquitin ligase atrogin-1 by inactivating Foxo factors[82], IGF-IR also phosphorylates Shc, which subsequently activates the RAS/Raf/MEK pathway leading to cell proliferation and mitogenesis[2]

The current treatment can be broadly categorized into three groups, i.e., (a) medical treatment, (b) physical exercise, and (c) surgery
This might potentially lead to reduced infiltration of inflammatory cells in the lungs of mice with lung damage and lower levels of TNF-1 and IL-6 production to minimize damage

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10.1016/j.biopha.2019.109729 134 WangQ.OuY.HuG.WenC.YueS.ChenC.et al (2020b)
