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Similar to the human GCLC, up-regulation of the human GCLM by -NF involved binding of transcription factor Nrf2 (possibly in complexes with other Jun or Maf proteins as in GCLC) to a functional ARE/EpRE site located at 302 of the human GCLM [104,134]

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In addition, CSF and serum analyses indicated increased levels of dopamine, TGF-1, IL-4 and IL-10, and a decrease in TNF- and IL-1 [71]

Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin

10.1016/j.jaci.2004.03.011