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Packer L, Weber SU, Rimbach G
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Relevant to understanding the role of GPx-1 in mediating cell signaling, modest (approximately twofold) overexpression of GPx-1 in permanently transfected cells was found to be sufficient to decrease accumulation of intracellular ROS and attenuate EGFR-mediated signal transduction in response to hydrogen peroxide or its cognate ligand, EGF
doi: 10.1164/rccm.201810-1931CI
