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Similarly, polymorphisms in GSTM1, the gene encoding the enzyme Glutathione S-Transferase Mu 1, have been associated with a lower incidence of cisplatin-induced neuropathy (Khrunin et al., 2010), while polymorphism of the CYP450 3A enzyme system can necessitate vincristine dose adjustments to prevent neurotoxicity (Mora et al., 2016)