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The cross docking of the identified hits with human GST revealed the potential binding specificity of the hits toward Wb GST

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However, this balance can be shifted toward the pro-oxidants when production of oxygen species is increased greatly (eg, following ingestion of certain chemicals or drugs) or when levels of antioxidants are diminished (eg, by inactivation of enzymes involved in disposal of oxygen species and by conditions that cause low levels of the antioxidants mentioned above)

Abbreviations ALS: Amyotrophic lateral sclerosis CCS: Copper chaperone for SOD1 CSF: Cerebrospinal fluid ISF: Interstitial fluid non- SOD1 ALS: Amyotrophic lateral sclerosis without mutations in the SOD1 gene PD: Parkinsons disease PSP: Progressive supranuclear palsy SOD1: Cu/Zn-superoxide dismutase SOD1 -ALS: Amyotrophic lateral sclerosis with mutations in the SOD1 gene References Andersen PM, Al-Chalabi A

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