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Advisory committees make non-binding recommendations to the FDA, which generally follows the recommendations but is not legally bound to do so

Arendt and Nexo proposed a diagnostic strategy for unexpected high plasma cobalamin that includes excluding supplementation, checking associated disease patterns and considering binding-protein or assay issues when the result does not fit (Arendt & Nexo, 2013)

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Following oral administration, Drug A is 100 % absorbed but 40 % bioavailable, while Drug B is 80 % absorbed and 60 % bioavailable