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Description
Study shows that high glucose inhibits autophagy in human mesangial cells (HMCs), as indicated by a decreased LC3-II/LC3-I ratio and accumulation of the selective autophagy substrate p62
Glutathione synthesis requires both glycine and cysteine , and these are in short supply in older humans
These effects are observed in preclinical cellular systems
At the pathological level, AD is characterized by the accumulation of amyloid plaques, neurofibrillary tangles (NFTs), and paired helical filaments (PHFs) (Glenner and Wong, 1986)
ASTRO 2005 Annual Meeting, 2005
