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doi:10.1038/ncb1846

Consequently, the elevated levels of free radicals can damage cellular structures, resulting in the accumulation of cytotoxic substances and ultimately leading to the death of substantia nigra cells, thereby triggering the onset of PD (Chittasupho et al., 2022)

doi: 10.21037/tau.2017.09.13 66 AgarwalALeisegangKMajzoubAHenkelRFinelliRSelvamMKPet al

Upon exposure to oxidative stress or electrophiles, Nrf2 translocate to the nucleus where it binds to antioxidant responsive elements (ARE)